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. 2014 Jul 31:2:514-24.
doi: 10.1016/j.mgene.2014.06.001. eCollection 2014 Dec.

Association of the histone-lysine N-methyltransferase MLL5 gene with coronary artery disease in Chinese Han people

Qinghua Yuan  1 , Xiang Xie  1 , Zhenyan Fu  1 , Xiang Ma  1 , Yining Yang  1 , Ding Huang  2 , Fen Liu  3 , Chuanfang Dai  1 , Yitong Ma  1
Affiliations

Association of the histone-lysine N-methyltransferase MLL5 gene with coronary artery disease in Chinese Han people

Qinghua Yuan et al. Meta Gene. .

Abstract

Background: MLL5, a member of the histone-lysine N-methyltransferase family, has been implicated in the control of the cell cycle progression and survival. The aim of this study was to explore the relationship between the interaction of histone-lysine N-methyltransferase MLL5 gene polymorphism and CAD in a Chinese Han population.

Methods: Using a case-control study of Chinese CAD patients (n = 565) and healthy controls (n = 694), we investigated the MLL5 gene polymorphism by the use of polymerase chain reaction fragment length polymorphism (PCR-RFLP) analysis.

Results: For total, the distribution of SNP1 (rs12671368) and SNP2 (rs2192932) genotypes showed a significant difference between CAD and control participants (P1 = 0.03, P2 = 0.02). For total the distribution of SNP1 (rs12671368) and SNP2 (rs2192932) alleles in the dominant model (GG vs. AA + AG) and the recessive model (AA vs. AG + GG) showed a significant difference between CAD and control participants (for allele: P1 < 0.01 and P2 = 0.05, for dominant model: P1 > 0.05 and P2 = 0.02, for recessive model: P1 = 0.03 and P2 = 0.78, respectively). For total the significant difference of the distribution of SNP1 and SNP2 in the dominant model and recessive model was retained after adjusting for covariates (for dominant model: SNP1 OR: 1.68, 95% confidence interval [CI]: 1.08-2.64, P = 0.02; SNP2 OR: 0.51, 95% CI: 0.36-0.72, P = 0.01; for recessive model: SNP1 OR: 1.84, 95% confidence interval [CI]: 1.28-2.64, P < 0.01; SNP2 OR: 0.65, 95% CI: 0.35-1.22, P = 0.18).

Conclusions: The GG genotype of rs12671368 and the AA genotype of rs2192932 in the MLL5 gene could be protective genetic markers of CAD.

Keywords: Case–control study; Coronary artery disease; MLL5; Single nucleotide polymorphism.

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Figures

Fig. 1
Fig. 1
A: tag SNPs' location in the MLL5 gene; B: (top) SNP1 (rs12671368) PCR products by bst4c1 enzyme digestion; (bottom) SNP2 (rs2192932) PCR products by Eco1301 enzyme digestion.
See this image and copyright information in PMC

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References

    1. Alkemade F.E., Gittenberger-de Groot A.C. Intrauterine exposure to maternal atherosclerotic risk factors increases the susceptibility to atherosclerosis in adult life. Arterioscler. Thromb. Vasc. Biol. 2007;27(10):2228–2235. - PubMed
    1. Barker D.J. Fetal programming of coronary heart disease. Trends Endocrinol. Metab. 2002;13(9):364–368. - PubMed
    1. Barnabas O., Wang H., Gao X.M. Role of estrogen in angiogenesis in cardiovascular diseases. J. Geriatr. Cardiol. 2013;10(4):377–382. - PMC - PubMed
    1. Bjorkegren J.L.M., Hagg S. Plasma cholesterol-induced lesion networks activated before regression of early, mature, and advanced atherosclerosis. PLoS Genet. 2014;10(2):e1004201. - PMC - PubMed
    1. Boomsma D., Busjahn A., Peltonen L. Classical twin studies and beyond. Nat. Rev. Genet. 2002;3(11):872–882. - PubMed

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