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. 2015 Jan;4(1):16-23.

The healing effect of scrophularia striata on experimental burn wounds infected to pseudomonas aeruginosa in rat

Nader Tanideh  1 , Mohammad Hossein Haddadi  2 , Mohammad Hossein Rokni-Hosseini  2 , Masood Hossienzadeh  3 , Davood Mehrabani  4 , Kourosh Sayehmiri  5 , Omid Koohi-Hossienabadi  6
Affiliations

The healing effect of scrophularia striata on experimental burn wounds infected to pseudomonas aeruginosa in rat

Nader Tanideh et al. World J Plast Surg. 2015 Jan.

Abstract

Background: The cause of death in burn patients after 48 hours of hospitalization has been reported to be bacterial infections. Recently, due to the compounds accelerating the healing process and the intense reduction of treatment side effects, medicinal plants are used to cure burn wound infections. This study aims to investigate the medicinal effect of the ethanolic extract of Scrophularia striata on burn wound infection in in-vivo and in-vitro in comparison with silver sulfadiazine (SSD).

Methods: One hundred and fifty male Sprague Dawley rats were divided into 3 equal groups. A hot plate of 1×1cm was used to create second degree burn wounds. The ethanolic extract of S. striata was provided through percolation method. Group 1 was treated with SSD, group 2 with S. striata, and group 3 was considered as control group. All animals were infected to Pseudomonas aeruginosa. On days 3, 7, 10, 14, and 21 after burn wound injury, the animals were euthanized and were evaluated histologically. The MIC and MBC were determined using the micro dilution method.

Results: The rate of wound healing was significantly greater in S. striata group in comparison to SSD and control groups.

Conclusion: S. striata contains was shown to have anti-bacterial and wound healing effects while this effect was significantly more than SSD denoting to its use when needed for burn wounds infected to P. aeruginosa.

Keywords: Healing; Pseudomonas aeruginosa; Scrophularia striata; Silver sulfadiazine; Wound.

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Figures

Fig. 1
Fig. 1
A: Comparison of wound healing according to mm2 in different time intervals and various treatment groups of Scrophularia striata, silver sulfadiazine and the control; B: Comparison of the percentage of burn wound healing in different time intervals and various groups; C: The macroscopic wound healing process in treatment groups with respect to the time interval
Fig. 2
Fig. 2
A-C: The values of remodeling criteria including collagenization, reepethelialization and granulation in different time intervals of 14, and 21 days and various treatment groups of Scrophularia striata, silver sulfadiazine and the control. D-F: Fourteen days after burn wound infection in various treatment groups of Scrophularia striata, silver sulfadiazine and the control, respectively (H&E×100); G: The increase of HPF (High Power Field) formation with respect to different time periods in various treatment groups of Scrophularia striata, silver sulfadiazine and the control; H and I: Comparison of inflammation and necrosis in various treatment groups of Scrophularia striata, silver sulfadiazine and the control at different time intervals.
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