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Comment
. 2015 Jan 20;42(1):10-2.
doi: 10.1016/j.immuni.2014.12.032.

Monocytes compensate Kupffer cell loss during bacterial infection

Kaaweh Molawi  1 , Michael H Sieweke  2
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Free article
Comment

Monocytes compensate Kupffer cell loss during bacterial infection

Kaaweh Molawi et al. Immunity. .
Free article

Abstract

Liver Kupffer cells (KCs) are self-maintained tissue-resident macrophages. In this issue of Immunity, Blériot et al. demonstrate that bacterial infection leads to KC necroptosis and quantitative replacement by monocyte-derived macrophages that contribute to antibacterial immunity and restoration of tissue integrity.

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