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Review
. 2015 Feb;30(2):150-9.
doi: 10.1002/mds.26099. Epub 2015 Jan 21.

Management of impulse control disorders in Parkinson's disease: Controversies and future approaches

Michael Samuel  1 , Maria Rodriguez-Oroz, Angelo Antonini, Jonathan M Brotchie, Kallol Ray Chaudhuri, Richard G Brown, Wendy R Galpern, Melissa J Nirenberg, Michael S Okun, Anthony E Lang
Affiliations
Review

Management of impulse control disorders in Parkinson's disease: Controversies and future approaches

Michael Samuel et al. Mov Disord. 2015 Feb.

Abstract

Impulse control disorders in Parkinson's disease are a group of impulsive behaviors most often associated with dopaminergic treatment. Presently, there is a lack of high quality evidence available to guide their management. This manuscript reviews current management strategies, before concentrating on the concept of dopamine agonist withdrawal syndrome and its implications for the management of impulse control disorders. Further, we focus on controversies, including the role of more recently available anti-parkinsonian drugs, and potential future approaches involving routes of drug delivery, nonpharmacological treatments (such as cognitive behavioral therapy and deep brain stimulation), and other as yet experimental strategies.

Keywords: Clinical Trials; Deep Brain Stimulation; Dopamine Agonist Withdrawal; Impulse control; Management; Parkinson's.

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References

    1. Napier TC, Corvol J, Grace AA, et al. Linking Neuroscience with Modern Concepts of Impulse Control Disorders in Parkinson’s disease. Mov Disord. 2014 In press. - PMC - PubMed
    1. Jahanshahi M, Obeso I, Baunez C, et al. Parkinson’s disease, the Subthalamic Nucleus, Inhibition and Impulsivity. Mov Disord. 2014 In press. - PubMed
    1. Weintraub D, David A, Evans A, et al. Clinical Spectrum of Impulse Control Disorders in Parkinson’s Disease. Mov Disord. 2014 In press. - PubMed
    1. Evans AH, Strafella AP, Weintraub D, et al. Impulsive and compulsive behaviors in Parkinson’s disease. Mov Disord. 2009;24:1561–1570. - PubMed
    1. Lyons KE, Friedman JH, Hermanowicz N, et al. Orally disintegrating selegiline in Parkinson patients with dopamine agonist-related adverse effects. Clin Neuropharmacol. 2010;33:5–10. - PubMed

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