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. 2015 Jan 22:5:7793.
doi: 10.1038/srep07793.

Transmission of tularemia from a water source by transstadial maintenance in a mosquito vector

Stina Bäckman  1 , Jonas Näslund  1 , Mats Forsman  1 , Johanna Thelaus  1
Affiliations

Transmission of tularemia from a water source by transstadial maintenance in a mosquito vector

Stina Bäckman et al. Sci Rep. .

Abstract

Mosquitoes are thought to function as mechanical vectors of Francisella tularensis subspecies holarctica (F. t. holarctica) causing tularemia in humans. We investigated the clinical relevance of transstadially maintained F. t. holarctica in mosquitoes. Aedes egypti larvae exposed to a fully virulent F. t. holarctica strain for 24 hours, were allowed to develop into adults when they were individually homogenized. Approximately 24% of the homogenates tested positive for F. t. DNA in PCR. Mice injected with the mosquito homogenates acquired tularemia within 5 days. This novel finding demonstrates the possibility of transmission of bacteria by adult mosquitoes having acquired the pathogen from their aquatic larval habitats.

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References

    1. Olsufiev N. in Hum. Dis. with Nat. foci (Pavlovsky, Y.) 219–281 (Foreign languages publishing house, 1966).
    1. Petersen J. M., Mead P. S. & Schriefer M. E. Francisella tularensis: an arthropod-borne pathogen. Vet. Res. 40, 7 (2009). - PMC - PubMed
    1. Lundstrom J. O. et al. Transstadial Transmission of Francisella tularensis holarctica in Mosquitoes, Sweden. Emerg. Infect. Dis. 17, 794–799 (2011). - PMC - PubMed
    1. Thelaus J. et al. Francisella tularensis Subspecies holarctica Occurs in Swedish Mosquitoes, Persists Through the Developmental Stages of Laboratory-Infected Mosquitoes and Is Transmissible During Blood Feeding. Microb. Ecol. 67, 96–107 (2014). - PMC - PubMed
    1. Keim P., Johansson A., Wagner D. M. & Epidemiology M. Molecular epidemiology, evolution, and ecology of Francisella. Ann. N. Y. Acad. Sci. 1105, 30–66 (2007). - PubMed

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