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Review
. 2015 Jan 6:10:157-74.
doi: 10.2147/CIA.S50670. eCollection 2015.

Optimal management of breast cancer in the elderly patient: current perspectives

Olivia Le Saux  1 , Bertrand Ripamonti  2 , Amandine Bruyas  3 , Olivier Bonin  4 , Gilles Freyer  5 , Marc Bonnefoy  6 , Claire Falandry  6
Affiliations
Review

Optimal management of breast cancer in the elderly patient: current perspectives

Olivia Le Saux et al. Clin Interv Aging. .

Abstract

Breast cancer (BC) is the most common female malignancy in the world and almost one third of cases occur after 70 years of age. Optimal management of BC in the elderly is a real challenge and requires a multidisciplinary approach, mainly because the elderly population is heterogeneous. In this review, we describe the various possibilities of treatment for localized or metastatic BC in an aging population. We provide an overview of the comprehensive geriatric assessment, surgery, radiotherapy, and adjuvant therapy for early localized BC and of chemotherapy and targeted therapies for metastatic BC. Finally, we attempt to put into perspective the necessary balance between the expected benefits and risks, especially in the adjuvant setting.

Keywords: breast cancer; chemotherapy; elderly; geriatric assessment; radiotherapy; surgery.

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References

    1. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin. 2011;61(2):69–90. - PubMed
    1. Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer. 2010;127(12):2893–2917. - PubMed
    1. Adami HO, Malker B, Holmberg L, Persson I, Stone B. The relation between survival and age at diagnosis in breast cancer. N Engl J Med. 1986;315(9):559–563. - PubMed
    1. Bastiaannet E, Portielje JE, van de Velde CJ, et al. Lack of survival gain for elderly women with breast cancer. Oncologist. 2011;16(4):415–423. - PMC - PubMed
    1. Bergman L, Kluck HM, van Leeuwen FE, et al. The influence of age on treatment choice and survival of elderly breast cancer patients in south-eastern Netherlands: a population-based study. Eur J Cancer. 1992;28A(8–9):1475–1480. - PubMed