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Review
. 2015 Jan 5:8:125-36.
doi: 10.2147/OTT.S72722. eCollection 2015.

Advances in the targeted therapy of liposarcoma

Zhonghai Guan  1 , Xiongfei Yu  1 , Haohao Wang  1 , Haiyong Wang  1 , Jing Zhang  1 , Guangliang Li  2 , Jiang Cao  3 , Lisong Teng  1
Affiliations
Review

Advances in the targeted therapy of liposarcoma

Zhonghai Guan et al. Onco Targets Ther. .

Abstract

Liposarcoma (LPS) is the most common type of soft-tissue sarcoma. Complete surgical resection is the only curative means for localized disease; however, both radiation and conventional cytotoxic chemotherapy remain controversial for metastatic or unresectable disease. An increasing number of trials with novel targeted therapy of LPS have provided encouraging data during recent years. This review will provide an overview of the advances in our understanding of LPS and summarize the results of recent trials with novel therapies targeting different genetic and molecular aberrations for different subtypes of LPS.

Keywords: myxoid; pleomorphic; round cell; soft-tissue sarcoma; well-/dedifferentiated.

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