Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2011 Apr;43(1):50-3.
doi: 10.5152/eajm.2011.10.

Post-traumatic glioblastoma multiforme: a case report

Suleyman Coskun  1 , Aysenur Coskun  2 , Nesrin Gursan  3 , Mehmet Dumlu Aydin  1
Affiliations
Case Reports

Post-traumatic glioblastoma multiforme: a case report

Suleyman Coskun et al. Eurasian J Med. 2011 Apr.

Abstract
in English, Turkish

Malignant glioma development after trauma is a rare occurrence. We report a glioblastoma multiforme case that developed after a depressed skull fracture. A 65-year-old man was admitted because of right sided hemiplegia, epilepsy and changes in consciousness due to a malignant glial tumor. He had been operated on for a left calvarial depression fracture caused by cerebral laceration thirty-five years before. Radiologic imaging revealed a large contrast-enhanced mass lesion at the left frontotemporoparietal junction under the depression site. The patient underwent urgent surgery, and radical excision of the mass was achieved. The histopathologic diagnosis was a high-grade glial tumor. Although the possibility of a pre-existing tumor rather than a trauma-induced tumor is very high, the presented case suggests that traumatic cerebral lesions may also be a predisposing factor for the development of malignant glial tumors.

Travma sonrasında malign glioma gelişimi çok nadir gelişen bir durumdur. Atmışbeş yaşındaki erkek hasta malign glial tümör nedeniyle gelişen sağ hemipleji, epilepsi ve bilinç kaybı ile kliniğimize kabul edildi. Hasta 35 yıl önce sol kalvaryal depresyon fraktürüne bağlı serebral laserasyon nedeniyle ameliyat edilmiştir. Radyolojik görüntülemede depresyon alanının altında sol frontotemporoparyetal loblarda kontrast tutan büyük bir kitle lezyonu göstermekteydi. Hasta acil operasyona alınarak radikal kitle eksizyonu uygulandı. Önceden mevcut bir tümör olma olasılığı travma kaynaklı tümörden çok yüksek olmasına rağmen, sunulan olguda travmatik beyin lezyonu malign glial tümör gelişiminde predispozan bir faktör olabilir.

Keywords: Brain injury; Glial cell tumors; Trauma.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
The patient had been operated on for a posttraumatic left temporoparietal depression fracture and cerebral lesion 35 years earlier. Traumatic and surgical incision scars are shown in the left temporoparietal region.
Figure 2.
Figure 2.
Axial contrast CT imaging revealed a contrast-enhancing mass lesion at the left lateral ventricular slit causing subfalcine herniation under the depressed temporal bone.
Figure 3.
Figure 3.
High-grade glioblastoma multiforme. Many of neoplastic cells show immunoreactivity to GFAP (GFAP, LM, ×100).
Figure 4.
Figure 4.
High-grade glioblastoma multiforme. Many of neoplastic cells show immunoreactivity to S-100 (S-100, LM, ×100).
Figure 5.
Figure 5.
A postoperative axial contrast CT showed no mass lesion 6 days after the operation. The midline shift and left lateral ventricular compression had resolved.
See this image and copyright information in PMC

References

    1. Annegers JF, Laws ER, Jr, Kurland LT. Head trauma and subsequent brain tumours. Neurosurgery. 1976;4:203–6. - PubMed
    1. Bohnen NI, Kurland LT. Epidemiology of brain tumours. Neuro- Glioblastoma Multiforme Following Cerebral Contusion. In: Vecht CJ, Vinken PJ, Bruyn GW, editors. Surg Neurol. Vol. 61. 2004. pp. 180–2. - PubMed
    1. Di Trapani G, Carnevale A, Scerrati M, Colosino C, Vaccario ML, Mei D. Post traumatic malignant glioma. Report of a case. Ital J Neurol Sci. 1996;17:283–6. - PubMed
    1. Diezel P. Gliom nach trauma. Frankfurt Z Path. 1949;60:316–26. - PubMed
    1. Hallervorden J. Oligodendroglion nach hirntrauma. Nervenartz. 1948;19:163–7. - PubMed

Publication types