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. 2013 Feb;45(1):39-42.
doi: 10.5152/eajm.2013.06.

The prevalence of positive serum anticardiolipin antibodies and asymptomatic bacteriuria in women with recurrent abortions

Zakarea Abdullah Yaseen Al-Khayat  1 , Nabeel Elia Waheda  1 , Nabaz Faisal Shaker  2
Affiliations

The prevalence of positive serum anticardiolipin antibodies and asymptomatic bacteriuria in women with recurrent abortions

Zakarea Abdullah Yaseen Al-Khayat et al. Eurasian J Med. 2013 Feb.

Abstract
in English, Turkish

Objective: The asymptomatic colonization of the urinary tract in pregnant women may result in severe medical and obstetric complications. The aim of this study was to study the prevalence of asymptomatic bacteriuria in cases of elevated levels of the anticardiolipin antibody in women who experience spontaneous abortions.

Materials and methods: A total of 12 women were enrolled in this case control study, including 60 patients with a history of three or more abortions and 60 healthy pregnant women. All participants were screened for ACL (IgG) and with a urine culture.

Results: Overall, 19 (31.7%) patients and seven (11.7%) healthy pregnant women were positive for ACL. The mean concentrations were 67.1±27.2 IU/mL in the patients and 17.41±6.12 IU/mL in the healthy controls (p≤0.05). In the 60 patients, only 17 (28.3%) had significant bacteriuria, whereas 5 (8.3%) women in the control group had significant bacteriuria. The statistical analysis revealed a highly significant difference. Of the 19 patients with a positive elevation of ACL, 11 (57.9%) had significant bacteriuria, and eight (42.1%) had non-significant bacteriuria. Six patients had ACL-negative results associated with significant bacteriuria. The statistical analysis revealed a highly significant difference.

Conclusion: A high serum anticardiolipin level was prevalent in women who experienced recurrent abortions associated with asymptomatic bacteriuria.

Amaç: Gebe kadınlarda idrar yolu asemptomatik kolonizasyonu ciddi tıbbi ve obstetrik komplikasyonlara neden olabilir. Bu çalışmanın amacı kendiliğinden düşük yapan kadınlarda antikardiyolipin antikor düzeylerinin artması durumunda asemptomatik bakteriüri prevalansını araştırmaktır.

Gereç ve yöntem: Bu vaka kontrollü çalışmaya 12 kadın dahil edildi. Geçmiş düşükleri üç ve daha fazla olan 60 ve sağlıklı 60 gebe çalışmaya dahil edildi. Tüm ACL (IgG) ve idrar kültürü açısından tarandı.

Bulgular: Tüm hastaların 19’unda (%31.7) ve yedi (%11.7) sağlıklı gebede ACL pozitifti. Ortalama konsantrasyonlar hastalarda 67.1±27.2 IU/mL, sağlıklı kontrollerde 17.41±6.12 IU/mL olarak tespit edildi. 60 hastadan sadece 17 hastada (%28.3) anlamlı bakteriüri varken sağlıklı kontrollerde 5 kişi (%8.3) anlamlı bakteriüri bulunmaktaydı. İstatistiksel analiz ile oldukça anlamlı fark olduğunu saptanmıştır. 19 hastanın 11’inde (%57.9) ACL’nin pozitif bir elevasyonu varken sekiz hastada (%42.1) anlamlı olmayan bakteriüri olduğu tespit edildi. Altı hastada ACL negatif sonuç ile ilişkili anlamlı bakteriüri mevcuttu.

Sonuç: Asemptomatik bakteriüri ile ilişkili tekrarlayan düşüklü kadınlarda yüksek serum antikardiyolipin düzeyi yaygın idi.

Keywords: Abortion; Anticardiolipin; Asymptomatic bacteriuria.

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References

    1. Kutter WH, Rote NS, Silver R. Antiphospholipid antibodies and reproduction. Am J Reprod Immunol. 1999;41:133–52. - PubMed
    1. Souza SS, Ferriani RA, Santos CM, Voltarelli JC. Immunological evaluation of patients with recurrent abortion. J Reprod Immunol. 2003;56:111–21. - PubMed
    1. Ebadi P, Eftekhar F, Asadi MR, Mehrabani D, Hasankhorami M, Karimi MH, Bagheri K. The prevalence of anticardiolipin antibodies and antisperm antibodies in patients with recurrent spontaneous abortion. IRCMJ. 2010;12:582–4.
    1. Levine JS, Branch DW, Rauch J. The antiphospholipid syndrome. N Engl J Med. 2002;346:752–63. - PubMed
    1. Petri M. Epidemiology of the antiphospholipid antibody syndrome. J Autoimmun. 2000;15:145–51. - PubMed

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