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. 2014 Oct;46(3):187-91.
doi: 10.5152/eajm.2014.36. Epub 2014 Jul 8.

Trace elements in children suffering from idiopathic nephrotic syndrome

Sebahat Tulpar  1 , Zubeyde Gunduz  1 , Ugur Sahin  2 , M Hakan Poyrazoglu  1 , Ismail Dursun  1 , Ruhan Dusunsel  1 , Funda Bastug  1
Affiliations

Trace elements in children suffering from idiopathic nephrotic syndrome

Sebahat Tulpar et al. Eurasian J Med. 2014 Oct.

Abstract
in English, Turkish

Objective: Trace elements play a significant role in several metabolic processes and often circulate in the blood binding to protein. The purpose of this study was to determine the status of selenium, zinc, and boron in idiopathic nephrotic syndrome patients in active and remission phases.

Materials and methods: Fourteen patients and fourteen healthy age-matched controls were included in the study. The selenium, zinc and boron level in plasma and urine were measured by the inductively coupled plasma mass spectrometry.

Results: The plasma levels of zinc and selenium were significantly lower in both active and remission patients (for all p=0.0001). The plasma boron level was significantly lower only in patients in active phase (p=0.0002 vs control). The concentrations of urinary boron and selenium were significantly higher during active phase compared with remission (p=0.0003 and 0.0001, respectively).

Conclusion: Supplementation with zinc, selenium and boron may be justified in patients suffering with this disease.

Amaç: Eser elementler birçok metabolik süreçte yer alır ve sıklıkla proteine bağlanarak dolaşırlar. Bu çalışmada nefrotik sendromlu hastaların aktivasyon ve remisyon dönemlerinde selenyum, çinko ve bor durumlarının araştırılması amaçlanmıştır.

Gereç ve yöntem: Ondört hasta ve 14 sağlıklı, benzer yaşta kontrol grubu çalışmaya alındı. Plazma ve idrarda selenyum, çinko ve bor düzeyleri indükleyici çiftleşmiş plazma kitle spektrometri yöntemi ile ölçüldü.

Bulgular: Plazma çinko ve selenyum düzeyleri hem aktivasyon hem de remisyon döneminde anlamlı olarak düşük bulundu (hepsi için p=0,0001). Plazma bor düzeyi sadece aktivasyon döneminde anlamlı olarak düşüktü (p=0,0002, kontrol ile karşılaştırıldığında). İdrar bor ve selenyum düzeyleri aktivasyon döneminde remisyon dönemine kıyasla anlamlı olarak yüksekti (p=0,0003 ve 0,0001, sırasıyla).

Sonuç: Nefrotik sendromlu hastaların çinko, selenyum ve bor açısından desteklenmesi gerekebilir.

Keywords: Boron; children; nephrotic syndrome; selenium; zinc.

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Figures

Figure 1.
Figure 1.
Trace elements concentrations of groups in plasma. Results are presented as means±SD. *p<0.001 versus control #p<0.01 versus patients in remission xp<0.001 versus patients in remission
Figure 2.
Figure 2.
Trace elements concentrations of groups in urine. Results are presented as means±SD. *p<0.001 versus patients in remission
See this image and copyright information in PMC

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