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Case Reports
. 2014 Oct;46(3):220-3.
doi: 10.5152/eajm.2014.33. Epub 2014 Jul 8.

Chromosomal Translocation t (10;19) (q11.2;q13.4) in an Infertile Male

Murat Kara  1 , Askin Sen  2 , Esin Sakallı Cetin  3 , Kursat Kargun  4
Affiliations
Case Reports

Chromosomal Translocation t (10;19) (q11.2;q13.4) in an Infertile Male

Murat Kara et al. Eurasian J Med. 2014 Oct.

Abstract
in English, Turkish

Chromosomal rearrangements are usually associated with male factor infertility. We report here a 34-year-old man suffering from primary infertility for 15 years. The cytogenetic analysis and investigation of Y-chromosome microdeletions were performed. A reciprocal balanced translocation t (10;19) (q11.2;q13.4) was found in oligozoospermic infertile men with no Y-chromosome microdeletions. In this case, we aimed to evaluate the 46,XY,t (10;19) (q11.2;q13.4) karyo-type, which was detected through a cytogenetic analysis of a person referred to our genetic laboratory due to primary infertility, in the light of the literature.

Kromozomal yeniden düzenlemeler genellikle erkek infertilitesi ile ilişkilidir. Bu makalede 15 yıldır primer infertilite şikayeti olan 34 yaşındaki bir erkek hastayı sunduk. Hastaya sitogenetik ve Y mikrodelesyon çalışması yapıldı. Sitogenetik sonucu, dengeli resiprokal translokasyon t (10;19) (q11.2;q13.4) görülürken, oligoazospermik infertil hastada Y-kromozom mikrodelesyon araştırması normal olarak bulundu. Bu olguda primer infertilite nedeniyle genetik laboratuvarımıza gönderilen kişiye yapılan sitogenetik analiz sonucunda tespit edilen 46,XY,t (10;19) (q11.2;q13.4) karyotipi literatür ışığı altında değerlendirmeyi amaçladık.

Keywords: Chromosomal translocation; infertility.

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Figures

Figure 1.
Figure 1.
Karyotype showing translocation between chromosomes 10 and 19.
Figure 2.
Figure 2.
G-banded chromosomes 10 and 19 with break points at 10 q11.2 and 19 q13.4.
See this image and copyright information in PMC

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