Striking the right balance: cortical modulation of the subthalamic nucleus-globus pallidus circuit
- PMID: 25611504
- DOI: 10.1016/j.neuron.2014.12.062
Striking the right balance: cortical modulation of the subthalamic nucleus-globus pallidus circuit
Abstract
The subthalamic nucleus-globus pallidus network is a potential source of oscillations in Parkinson's disease, but the mechanism is unknown. In this issue of Neuron, Chu et al. (2015) present a cortically driven form of heterosynaptic plasticity that could promote oscillatory activity after dopamine depletion.
Copyright © 2015 Elsevier Inc. All rights reserved.
Comment on
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Heterosynaptic regulation of external globus pallidus inputs to the subthalamic nucleus by the motor cortex.Neuron. 2015 Jan 21;85(2):364-76. doi: 10.1016/j.neuron.2014.12.022. Epub 2015 Jan 8. Neuron. 2015. PMID: 25578364 Free PMC article.
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