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. 2015;83(2):141-7.
doi: 10.1159/000369251. Epub 2015 Jan 22.

Molecular insights into the possible role of Kir4.1 and Kir5.1 in thyroid hormone biosynthesis

Helton Estrela Ramos  1 , Magnus Régios Dias da Silva, Aurore Carré, Joaquim Custódio Silva Jr, Rolf Matias Paninka, Taise Lima Oliveira, Elodie Tron, Mireille Castanet, Michel Polak
Affiliations

Molecular insights into the possible role of Kir4.1 and Kir5.1 in thyroid hormone biosynthesis

Helton Estrela Ramos et al. Horm Res Paediatr. 2015.

Abstract

Introduction: Thyroid morphogenesis is a complex process. Inwardly rectifying potassium (Kir) genes play a role in hormone release, cell excitability, pH and K(+) homeostasis in many tissues.

Objectives: To investigate the thyroid developmental expression of three members, Kir4.1, Kir4.2 and Kir5.1, in mice. To postulate the K(+) channel role in thyroid hormone secretion.

Material and methods: Quantitative RT-PCR analysis of Kir4.1, Kir4.2 and Kir5.1 in mice of different stages (E13.5-E18.5).

Results: mRNA for Kir4.1, Kir4.2 and Kir5.1 were identified and increased with age in mice. Both Kir4.1 and Kir4.2 genes are better expressed after E16.5. Kir4.2 greatly increases from E13.5 to E16.5 (p ≤ 0.05).

Conclusion: Quantitative PCR shows that the mouse thyroid presents increased expression for Kir channels during development. The role of Kir in thyroid morphogenesis and differentiation might be understood in future studies. We speculate that thyroglobulin trafficking might be modulated by Kir4.1/5.1.

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