On the role of concentration-effect relationships in safety pharmacology: only the dose makes a drug not to be poison!
- PMID: 25612662
- PMCID: PMC4456140
- DOI: 10.1111/bcp.12593
On the role of concentration-effect relationships in safety pharmacology: only the dose makes a drug not to be poison!
Comment on
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The role of concentration-effect relationships in the assessment of QTc interval prolongation.Br J Clin Pharmacol. 2015 Jan;79(1):117-31. doi: 10.1111/bcp.12443. Br J Clin Pharmacol. 2015. PMID: 24938719 Free PMC article. Review.
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The role of concentration--effect relationships in the QTc interval prolongation: case sotalol.Br J Clin Pharmacol. 2015 Jun;79(6):1040-1. doi: 10.1111/bcp.12574. Br J Clin Pharmacol. 2015. PMID: 25534550 Free PMC article. No abstract available.
References
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- Neuvonen PJ, Elonen E. The role of concentration-effect relationships in the QTc interval prolongation - Case sotalol. Br J Clin Pharmacol. 2014 . doi: 10.1111/bcp.12574. - DOI - PMC - PubMed
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- Gobburu J. Clinical Pharmacology and Biopharmaceutics Review. Approval Package for Application No. 19-865/S-010 . Center for Drug Evaluation and Research. Food and Drug Administration. 22 May 2000. Available at http://www.accessdata.fda.gov/drugsatfda_docs/nda/2001/19-865S010_Betapa... (last accessed on 18 Oct 2014)
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- Stumpf W. The dose makes the medicine. Drug Discov Today. 2006;11:550–5. - PubMed
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