Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2015 Jun;79(6):1042-3.
doi: 10.1111/bcp.12593.

On the role of concentration-effect relationships in safety pharmacology: only the dose makes a drug not to be poison!

Affiliations
Comment

On the role of concentration-effect relationships in safety pharmacology: only the dose makes a drug not to be poison!

Oscar Della Pasqua. Br J Clin Pharmacol. 2015 Jun.
No abstract available

PubMed Disclaimer

Comment on

References

    1. France N, Della Pasqua O. The role of concentration–effect relationships in the assessment of QTc interval prolongation. Br J Clin Pharmacol. 2015;79:117–31. - PMC - PubMed
    1. Neuvonen PJ, Elonen E. The role of concentration-effect relationships in the QTc interval prolongation - Case sotalol. Br J Clin Pharmacol. 2014 . doi: 10.1111/bcp.12574. - DOI - PMC - PubMed
    1. Gobburu J. Clinical Pharmacology and Biopharmaceutics Review. Approval Package for Application No. 19-865/S-010 . Center for Drug Evaluation and Research. Food and Drug Administration. 22 May 2000. Available at http://www.accessdata.fda.gov/drugsatfda_docs/nda/2001/19-865S010_Betapa... (last accessed on 18 Oct 2014)
    1. Stumpf W. The dose makes the medicine. Drug Discov Today. 2006;11:550–5. - PubMed
    1. Chain A, Dieleman J, van Noord C, Hofman A, Stricker B, Danhof M, Sturkenboom M, Della PasquaO. Not-in-trial simulation I: bridging cardiovascular risk from clinical trials to real life conditions. Br J Clin Pharmacol. 2013;76:964–72. - PMC - PubMed

MeSH terms