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. 2015 Apr;19(4):626-34.
doi: 10.1007/s10461-015-0998-x.

Comprehensive evaluation of caregiver-reported antiretroviral therapy adherence for HIV-infected children

Rachel C Vreeman  1 , Winstone M Nyandiko, Hai Liu, Wanzhu Tu, Michael L Scanlon, James E Slaven, Samuel O Ayaya, Thomas S Inui
Affiliations

Comprehensive evaluation of caregiver-reported antiretroviral therapy adherence for HIV-infected children

Rachel C Vreeman et al. AIDS Behav. 2015 Apr.

Abstract

For HIV-infected children, adherence to antiretroviral therapy (ART) is often assessed by caregiver report but there are few data on their validity. We conducted prospective evaluations with 191 children ages 0-14 years and their caregivers over 6 months in western Kenya to identify questionnaire items that best predicted adherence to ART. Medication Event Monitoring Systems(®) (MEMS, MWV/AARDEX Ltd., Switzerland) electronic dose monitors were used as external criterion for adherence. We employed a novel variable selection tool using the LASSO technique with logistic regression to identify items best correlated with dichotomized MEMS adherence (≥90 or <90 % doses taken). Nine of 48 adherence items were identified as the best predictors of adherence, including missed or late doses in the past 7 days, problems giving the child medicines, and caregiver-level factors like not being present at medication taking. These items could be included in adherence assessment tools for pediatric patients.

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Figure I
Figure I
Adherence to ART by Medication Event Monitoring Systems
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