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Review
. 2015 Jan 23;47(1):e131.
doi: 10.1038/emm.2014.84.

Epstein-Barr virus latent genes

Myung-Soo Kang  1 , Elliott Kieff  2
Affiliations
Review

Epstein-Barr virus latent genes

Myung-Soo Kang et al. Exp Mol Med. .

Abstract

Latent Epstein-Barr virus (EBV) infection has a substantial role in causing many human disorders. The persistence of these viral genomes in all malignant cells, yet with the expression of limited latent genes, is consistent with the notion that EBV latent genes are important for malignant cell growth. While the EBV-encoded nuclear antigen-1 (EBNA-1) and latent membrane protein-2A (LMP-2A) are critical, the EBNA-leader proteins, EBNA-2, EBNA-3A, EBNA-3C and LMP-1, are individually essential for in vitro transformation of primary B cells to lymphoblastoid cell lines. EBV-encoded RNAs and EBNA-3Bs are dispensable. In this review, the roles of EBV latent genes are summarized.

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Figures

Figure 1
Figure 1
Latent membrane protein-1 (LMP1)-mediated activation of natural factor-κB (NF-κB) signaling.
See this image and copyright information in PMC

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