Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015 Feb;19(1):53-7.
doi: 10.1007/s40291-015-0130-y.

TNF-α -308 G/A as a risk marker of cervical cancer progression in the Polish population

Andrzej Roszak  1 , Matthew Misztal, Anna Sowińska, Paweł P Jagodziński
Affiliations

TNF-α -308 G/A as a risk marker of cervical cancer progression in the Polish population

Andrzej Roszak et al. Mol Diagn Ther. 2015 Feb.

Abstract

Background and objective: There are inconclusive data on the tumor necrosis factor-α (TNF-α) -308 G/A (rs1800629) polymorphism as a risk factor for cervical carcinogenesis.

Methods: Using high-resolution melting curve analysis, we investigated the prevalence of the TNF-α -308 G/A transition (rs1800629) in patients with cervical cancer (n = 362) and control subjects (n = 399).

Results: The p trend value calculated for the TNF-α -308 G/A transition was statistically significant (p trend = 0.026) for all patients. Logistic regression analysis with adjustment for age demonstrated that the A/A versus G/G genotype was significantly associated with cervical tumors. The adjusted odds ratio (OR) was 1.599 (95 % confidence interval [CI] 1.017-2.513; p = 0.042). Stratification of patients on the basis of the tumor stage revealed no contribution of the TNF-α -308 G/A transition to cervical cancer in stages I and II. However, we found a significant trend for the p value, as well as the contribution of TNF-α -308 G/A to cervical cancer, in stages III and IV. The p trend value was 0.003 in this group of patients. Moreover, logistic regression analysis with adjustment for age demonstrated that the adjusted OR for A/A versus G/G was 2.014 (95 % CI 1.122-3.613; p = 0.019) and the adjusted OR for A/A or A/G versus G/G was 1.583 (95 % CI 1.025-2.444; p = 0.038) for cervical cancer in stages III and IV.

Conclusion: Our results indicate that the TNF-α -308 G/A transition is a risk factor for cervical cancer, particularly in stages III and IV.

PubMed Disclaimer

References

    1. Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):3195-9 - PubMed
    1. Mol Biol Rep. 2012 Mar;39(3):2683-8 - PubMed
    1. PLoS One. 2013 Aug 27;8(8):e69201 - PubMed
    1. Biochem Biophys Res Commun. 2005 Aug 26;334(2):588-92 - PubMed
    1. Tumour Biol. 2014 Mar;35(3):2561-4 - PubMed

Publication types

MeSH terms

Substances