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Comment
. 2015 Feb;64(2):341-3.
doi: 10.2337/db14-1447.

Further insight on the limits of success of glycemic control in type 1 diabetes

Barbara E K Klein  1 , Ronald Klein  2
Affiliations
Comment

Further insight on the limits of success of glycemic control in type 1 diabetes

Barbara E K Klein et al. Diabetes. 2015 Feb.
No abstract available

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Figures

Figure 1
Figure 1
The estimated 5-year incidence (A) and progression (B) of diabetic retinopathy by level of HbA1c and duration of diabetes. Derived from data from the first three study visits of the Wisconsin Epidemiologic Study of Diabetic Retinopathy. In a general population, individuals with type 1 diabetes and HbA1c of 7.8% (approximately the same HbA1c level of the intensive and conventional groups after the DCCT) were likely to develop retinopathy or have their retinopathy progress within a 5-year interval. Even individuals with HbA1c levels of 6.0% (a level that most patients do not achieve or sustain) and a short duration of diabetes were likely to have incident or progressive retinopathy within 5 years. The risk of incidence and progression rose for individuals with higher levels of HbA1c.
See this image and copyright information in PMC

Comment on

References

    1. Wagener HP, Dry TJ, Wilder RM. Retinitis in diabetes. N Engl J Med 1934;211:1131–1137
    1. The Diabetes Control and Complications Trial Research Group . The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med 1993;329:977–986 - PubMed
    1. Klein R, Klein BE. Are individuals with diabetes seeing better? a long-term epidemiological perspective. Diabetes 2010;59:1853–1860 - PMC - PubMed
    1. Antonetti DA, Klein R, Gardner TW. Diabetic retinopathy. N Engl J Med 2012;366:1227–1239 - PubMed
    1. LeCaire TJ, Palta M, Klein R, Klein BE, Cruickshanks KJ. Assessing progress in retinopathy outcomes in type 1 diabetes: comparing findings from the Wisconsin Diabetes Registry Study and the Wisconsin Epidemiologic Study of Diabetic Retinopathy. Diabetes Care 2013;36:631–637 - PMC - PubMed

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