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Review
. 2015 Feb:32:71-7.
doi: 10.1016/j.coi.2015.01.004. Epub 2015 Jan 20.

Innate lymphoid cells: new insights into function and development

Victor S Cortez  1 , Michelle L Robinette  1 , Marco Colonna  2
Affiliations
Review

Innate lymphoid cells: new insights into function and development

Victor S Cortez et al. Curr Opin Immunol. 2015 Feb.

Abstract

Here, we illustrate the complexity of ILC subsets and discuss novel functions, focusing on emerging mechanisms of crosstalk with other immune cells and the microbiota. Furthermore, we highlight recent insights into the development of ILCs, including the common pathways they share as well as points of divergence between ILC groups and subsets.

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Figures

Figure 1
Figure 1
ILC developmental tree with known restricted progenitors and the differentiated cell populations they give rise to. ILCs are divided into group 1, group 2, and group 3 based upon common effector cytokine production.
See this image and copyright information in PMC

References

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    1. Daussy C, Faure F, Mayol K, Viel S, Gasteiger G, Charrier E, Bienvenu J, Henry T, Debien E, Hasan UA, et al. T-bet and Eomes instruct the development of two distinct natural killer cell lineages in the liver and in the bone marrow. J Ex Med. 2014;211(3):563–577. This work shows that T-bet+Eomes− cells do not give rise to T-bet+Eomes+ NK cells, demonstrating they are not immature NK cells but a distinct population, the ILC1.

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