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Review
. 2015 Apr;13(2):125-30.
doi: 10.1007/s11914-015-0257-0.

Diet, gut microbiome, and bone health

Connie M Weaver  1
Affiliations
Review

Diet, gut microbiome, and bone health

Connie M Weaver. Curr Osteoporos Rep. 2015 Apr.

Abstract

Interactions between the environment, the gut microbiome, and host characteristics that influence bone health are beginning to be explored. This is the first area where functional benefits from diet-induced changes in the gut microbiome have been reported for healthy people. Several prebiotics that reach the lower intestine have resulted in an altered gut microbiome that is thought to enhance fermentation of the fibers to produce short-chain fatty acids. These changes are positively correlated with increases in fractional calcium absorption in adolescents and with increases in measures of bone density and strength in animal models. New methodologies are available to explore mechanisms and to refine intervention strategies.

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Figures

Fig 1
Fig 1. Model for role of prebiotic fiber effects
Fig 2
Fig 2. Mechanistic outcomes predicted calcium absorption and BMD in rats. Adapted from [24]
Fig 3
Fig 3. Bacterial communities differ by GOS treatment. Reprinted with permission from [26]. Copyright (2011) American Chemical Society
See this image and copyright information in PMC

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