Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2015 Mar;16(1):55-65.
doi: 10.1007/s11154-015-9309-0.

The role of gut microbiota in the development of type 1, type 2 diabetes mellitus and obesity

Ningwen Tai  1 , F Susan Wong, Li Wen
Affiliations
Review

The role of gut microbiota in the development of type 1, type 2 diabetes mellitus and obesity

Ningwen Tai et al. Rev Endocr Metab Disord. 2015 Mar.

Abstract

Diabetes is a group of metabolic disorders characterized by persistent hyperglycemia and has become a major public health concern. Autoimmune type 1 diabetes (T1D) and insulin resistant type 2 diabetes (T2D) are the two main types. A combination of genetic and environmental factors contributes to the development of these diseases. Gut microbiota have emerged recently as an essential player in the development of T1D, T2D and obesity. Altered gut microbiota have been strongly linked to disease in both rodent models and humans. Both classic 16S rRNA sequencing and shot-gun metagenomic pyrosequencing analysis have been successfully applied to explore the gut microbiota composition and functionality. This review focuses on the association between gut microbiota and diabetes and discusses the potential mechanisms by which gut microbiota regulate disease development in T1D, T2D and obesity.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest: the authors declare no conflict of interest

References

    1. Kamada N, et al. Role of the gut microbiota in immunity and inflammatory disease. Nat Rev Immunol. 2013;13(5):321–335. - PubMed
    1. Geuking MB, et al. The interplay between the gut microbiota and the immune system. Gut Microbes. 2014;5(3) - PMC - PubMed
    1. Vieira SM, Pagovich OE, Kriegel MA. Diet, microbiota and autoimmune diseases. Lupus. 2014;23(6):518–526. - PMC - PubMed
    1. Nielsen DS, et al. Beyond genetics. Influence of dietary factors and gut microbiota on type 1 diabetes. FEBS Lett. 2014 - PubMed
    1. Vaarala O. Human intestinal microbiota and type 1 diabetes. Curr Diab Rep. 2013;13(5):601–607. - PubMed

Publication types

MeSH terms