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. 1989 Nov;3(5):647-54.
doi: 10.1016/0896-6273(89)90275-4.

Chromosomal localization of GABAA receptor subunit genes: relationship to human genetic disease

V J Buckle  1 , N Fujita, A S Ryder-Cook, J M Derry, P J Barnard, R V Lebo, P R Schofield, P H Seeburg, A N Bateson, M G Darlison, et al.
Affiliations

Chromosomal localization of GABAA receptor subunit genes: relationship to human genetic disease

V J Buckle et al. Neuron. 1989 Nov.

Abstract

Hybridization of GABAA receptor probes to human chromosomes in situ and to DNA from sorted human chromosomes has localized the genes encoding a beta subunit and three isoforms of the alpha subunit. The alpha 2 and beta genes are both located on chromosome 4 in bands p12-p13 and may be adjacent. The alpha 1 gene is on chromosome 5 (bands q34-q35) and the alpha 3 gene is on the X chromosome. The alpha 3 locus was mapped also on the mouse X chromosome using genetic break-point analysis in an interspecies pedigree. The combined results locate the human alpha 3 gene within band Xq28, in a location that makes it a candidate gene for the X-linked form of manic depression.

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