doi: 10.1016/0304-3940(89)90021-9.
Voltage-dependent GABA-induced modulation of calcium currents in chick sensory neurons
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- PMID: 2562057
- DOI: 10.1016/0304-3940(89)90021-9
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Voltage-dependent GABA-induced modulation of calcium currents in chick sensory neurons
Neurosci Lett.
.
Abstract
Externally applied gamma-aminobutyric acid (GABA) quickly and reversibly reduces by 60% voltage activated Ca2+ currents in chick dorsal root ganglion cells. This action is antagonized by depolarization, with characteristic time and voltage requirements. Intracellular perfusion with guanosine 5'-O-(3-thiotriphosphate) (GTP gamma S) or guanosine 5'-O-(2-thiodiphosphate) (GDP beta S) mimicks and blocks the GABA effect, respectively. A 3-state model describing the reactions involved is proposed.
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