Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2015 Jan 26;7(1):106-15.
doi: 10.4252/wjsc.v7.i1.106.

Advances in cellular technology in the hematology field: What have we learned so far?

Gustavo Torres de Souza  1 , Claudinéia Pereira Maranduba  1 , Camila Maurmann de Souza  1 , Danielle Luciana Aurora Soares do Amaral  1 , Francisco Carlos da Guia  1 , Rafaella de Souza Salomão Zanette  1 , João Vitor Paes Rettore  1 , Natana Chaves Rabelo  1 , Lucas Mendes Nascimento  1 , Ícaro França Navarro Pinto  1 , Júlia Boechat Farani  1 , Abrahão Elias Hallack Neto  1 , Fernando de Sá Silva  1 , Carlos Magno da Costa Maranduba  1 , Angelo Atalla  1
Affiliations
Review

Advances in cellular technology in the hematology field: What have we learned so far?

Gustavo Torres de Souza et al. World J Stem Cells. .

Abstract

Despite the advances in the hematology field, blood transfusion-related iatrogenesis is still a major issue to be considered during such procedures due to blood antigenic incompatibility. This places pluripotent stem cells as a possible ally in the production of more suitable blood products. The present review article aims to provide a comprehensive summary of the state-of-the-art concerning the differentiation of both embryonic stem cells and induced pluripotent stem cells to hematopoietic cell lines. Here, we review the most recently published protocols to achieve the production of blood cells for future application in hemotherapy, cancer therapy and basic research.

Keywords: Embryonic stem cells; Hematopoietic stem cells; Induced pluripotent stem cells; Progenitor; Reprogramming.

PubMed Disclaimer

Similar articles

See all similar articles

References

    1. Goodnough LT, Levy JH, Murphy MF. Concepts of blood transfusion in adults. Lancet. 2013;381:1845–1854. - PubMed
    1. Liu QP, Sulzenbacher G, Yuan H, Bennett EP, Pietz G, Saunders K, Spence J, Nudelman E, Levery SB, White T, et al. Bacterial glycosidases for the production of universal red blood cells. Nat Biotechnol. 2007;25:454–464. - PubMed
    1. Tan Y, Qiu Y, Xu H, Ji S, Li S, Gong F, Zhang Y. Decreased immunorejection in unmatched blood transfusions by attachment of methoxypolyethylene glycol on human red blood cells and the effect on D antigen. Transfusion. 2006;46:2122–2127. - PubMed
    1. Bagnis C, Chapel S, Chiaroni J, Bailly P. A genetic strategy to control expression of human blood group antigens in red blood cells generated in vitro. Transfusion. 2009;49:967–976. - PubMed
    1. Shander A, Hofmann A, Gombotz H, Theusinger OM, Spahn DR. Estimating the cost of blood: past, present, and future directions. Best Pract Res Clin Anaesthesiol. 2007;21:271–289. - PubMed

LinkOut - more resources