Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2015 Jan 18;6(1):106-16.
doi: 10.5312/wjo.v6.i1.106.

Hand bone mass in rheumatoid arthritis: A review of the literature

Gamze Kilic  1 , Salih Ozgocmen  1
Affiliations
Review

Hand bone mass in rheumatoid arthritis: A review of the literature

Gamze Kilic et al. World J Orthop. .

Abstract

Rheumatoid arthritis (RA) is a common chronic inflammatory disease and periarticular osteoporosis or osteopenia of the inflamed hand joints is an early feature of RA. Quantitative measurement of hand bone loss may be an outcome measure for the detection of joint destruction and disease progression in early RA. This systematic review examines the published literature reporting hand bone mass in patients with RA, particularly those using the dual X-ray absorptiometry (DXA) methods. The majority of the studies reported that hand bone loss is associated with disease activity, functional status and radiological progression in early RA. Quantitative measurement of hand bone mineral density by DXA may be a useful and practical outcome measure in RA and may be predictive for radiographic progression or functional status in patients with early RA.

Keywords: Dual X-ray absorptiometry; Hand bone density; Osteoporosis; Periarticular; Rheumatoid arthritis.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Flow chart. RA: Rheumatoid arthritis; DXA: Dual-X-ray absorptiometry.
See this image and copyright information in PMC

References

    1. Hansen M, Florescu A, Stoltenberg M, Pødenphant J, Pedersen-Zbinden B, Hørslev-Petersen K, Hyldstrup L, Lorenzen I. Bone loss in rheumatoid arthritis. Influence of disease activity, duration of the disease, functional capacity, and corticosteroid treatment. Scand J Rheumatol. 1996;25:367–376. - PubMed
    1. Güler-Yüksel M, Klarenbeek NB, Goekoop-Ruiterman YP, de Vries-Bouwstra JK, van der Kooij SM, Gerards AH, Ronday HK, Huizinga TW, Dijkmans BA, Allaart CF, et al. Accelerated hand bone mineral density loss is associated with progressive joint damage in hands and feet in recent-onset rheumatoid arthritis. Arthritis Res Ther. 2010;12:R96. - PMC - PubMed
    1. Devlin J, Lilley J, Gough A, Huissoon A, Holder R, Reece R, Perkins P, Emery P. Clinical associations of dual-energy X-ray absorptiometry measurement of hand bone mass in rheumatoid arthritis. Br J Rheumatol. 1996;35:1256–1262. - PubMed
    1. Haugeberg G, Green MJ, Quinn MA, Marzo-Ortega H, Proudman S, Karim Z, Wakefield RJ, Conaghan PG, Stewart S, Emery P. Hand bone loss in early undifferentiated arthritis: evaluating bone mineral density loss before the development of rheumatoid arthritis. Ann Rheum Dis. 2006;65:736–740. - PMC - PubMed
    1. Saville PD. A quantitative approach to simple radiographic diagnosis of osteoporosis: its application to the osteoporosis of rheumatoid arthritis. Arthritis Rheum. 1967;10:416–422. - PubMed

LinkOut - more resources