Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015 Mar;12(3):233-5, 3 p following 235.
doi: 10.1038/nmeth.3254. Epub 2015 Jan 26.

Inferring biological tasks using Pareto analysis of high-dimensional data

Yuval Hart  1 , Hila Sheftel  1 , Jean Hausser  1 , Pablo Szekely  1 , Noa Bossel Ben-Moshe  2 , Yael Korem  1 , Avichai Tendler  1 , Avraham E Mayo  1 , Uri Alon  1
Affiliations

Inferring biological tasks using Pareto analysis of high-dimensional data

Yuval Hart et al. Nat Methods. 2015 Mar.

Abstract

We present the Pareto task inference method (ParTI; http://www.weizmann.ac.il/mcb/UriAlon/download/ParTI) for inferring biological tasks from high-dimensional biological data. Data are described as a polytope, and features maximally enriched closest to the vertices (or archetypes) allow identification of the tasks the vertices represent. We demonstrate that human breast tumors and mouse tissues are well described by tetrahedrons in gene expression space, with specific tumor types and biological functions enriched at each of the vertices, suggesting four key tasks.

PubMed Disclaimer

References

    1. Nucleic Acids Res. 2011 Jan;39(Database issue):D691-7 - PubMed
    1. Ecol Evol. 2013 Jun;3(6):1471-83 - PubMed
    1. Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15545-50 - PubMed
    1. Science. 2009 Jul 24;325(5939):429-32 - PubMed
    1. Nucleic Acids Res. 2000 Jan 1;28(1):27-30 - PubMed

Publication types

LinkOut - more resources