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Review
. 2015 Jul:114:97-101.
doi: 10.1016/j.biochi.2015.01.007. Epub 2015 Jan 23.

Selenocysteine incorporation: A trump card in the game of mRNA decay

Sumangala P Shetty  1 , Paul R Copeland  2
Affiliations
Review

Selenocysteine incorporation: A trump card in the game of mRNA decay

Sumangala P Shetty et al. Biochimie. 2015 Jul.

Abstract

The incorporation of the 21st amino acid, selenocysteine (Sec), occurs on mRNAs that harbor in-frame stop codons because the Sec-tRNA(Sec) recognizes a UGA codon. This sets up an intriguing interplay between translation elongation, translation termination and the complex machinery that marks mRNAs that contain premature termination codons for degradation, leading to nonsense mediated mRNA decay (NMD). In this review we discuss the intricate and complex relationship between this key quality control mechanism and the process of Sec incorporation in mammals.

Keywords: NMD; Selenocysteine; mRNA decay.

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Figures

Figure 1
Figure 1
Diagram of the factors required for selenocysteine incorporation in eukaryotes.
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