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. 2015 May;20(5):549-50.
doi: 10.1038/mp.2014.194. Epub 2015 Jan 27.

Dopaminergic differentiation of schizophrenia hiPSCs

B J Hartley  1 , N Tran  1 , I Ladran  1 , K Reggio  1 , K J Brennand  1
Affiliations

Dopaminergic differentiation of schizophrenia hiPSCs

B J Hartley et al. Mol Psychiatry. 2015 May.
No abstract available

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig. 1
Fig. 1. Differentiation of control and SZ hiPSC DA NPCs
A. Schematic of SHH/FGF8 hiPSC DA neural differentiation. B. NPCs patterned with SHH and FGF8 differentiation to neurons expressing the DA marker tyrosine hydroxylase (TH) (red) and ßIII-TUBULIN (green). Scale bar 10μm. C. Schematic of SHH/FGF8/CHIR99021 hiPSC DA neural differentiation. D. No significant differences (nd) in the yield of TH-positive neurons after 4-weeks of neuronal differentiation between control and SZ DA NPCs when cultured with SHH, FGF8 and CHIR99021. Numbers within the bars indicate total number of DAPI-positive nuclei counted. E. Limited overlap in FOXA2-positive and TH-positive neuronal population. Scale bar 100μm.
See this image and copyright information in PMC

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References

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