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. 2015 Feb;9(2):891-896.
doi: 10.3892/ol.2014.2721. Epub 2014 Nov 20.

NPY1R is a novel peripheral blood marker predictive of metastasis and prognosis in breast cancer patients

Lei Liu  1 , Qian Xu  2 , Luyang Cheng  1 , Chunhu Ma  3 , Lijun Xiao  1 , Dawei Xu  1 , Yaxian Gao  1 , Jianping Wang  1 , Hongru Song  1
Affiliations

NPY1R is a novel peripheral blood marker predictive of metastasis and prognosis in breast cancer patients

Lei Liu et al. Oncol Lett. 2015 Feb.

Abstract

The aim of the current study was to evaluate a novel tumor marker, neuropeptide Y receptor Y1 (NPY1R), for the detection of circulating cancer cells and to investigate its clinical significance in breast cancer patients. The Digital Gene Expression Displayer tool of the Cancer Genome Anatomy Project was used to identify the marker gene NPY1R, which is able to detect circulating cancer cells. Nested quantitative polymerase chain reaction was performed to correlate the NPY1R expression levels with the clinicopathological features of 142 breast cancer patients. A follow-up study of 131 of the breast cancer patients was conducted for 38 months. Compared with the 60 normal control individuals, NPY1R was highly expressed in the cancer patients (P<0.01). These high levels of NPY1R expression were positively correlated with the clinical stage and lymph node metastasis status of the disease, as well as with the status of the estrogen and progesterone receptors (P<0.05). Breast cancer patients with circulating cancer cells that expressed NPY1R exhibited shorter tumor-specific survival when compared with those with no NPY1R expression (P<0.01). Additionally, the mortality rate was associated with HER2 expression in the NPY1R positive and negative groups. These results indicate that NPY1R may serve as a useful marker to predict breast cancer metastasis and to evaluate the prognosis of breast cancer patients.

Keywords: breast cancer; circulating cancer cells; neuropeptide Y receptor Y1; tumor marker.

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Figures

Figure 1
Figure 1
(A) Expression levels of the neuropeptide Y receptor Y1 (NPY1R) gene in the peripheral blood of breast cancer patients compared with normal controls. *P<0.01. (B) Receiver operating characteristic (ROC) curve of the NPY1R marker gene. Area under the curve, 0.855.
Figure 2
Figure 2
Kaplan-Meier survival analysis of breast cancer patients grouped according to neuropeptide Y receptor Y1 status (NPY1R) in the peripheral blood.
See this image and copyright information in PMC

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