Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015 Jan 13:4:16.
doi: 10.1186/s40064-015-0797-x. eCollection 2015.

Activity of Haliscosamine against Fusarium oxysporum f.sp. melonis: in vitro and in vivo analysis

Belakssem El Amraoui  1 , Jean François Biard  2 , Fatima Ez-Zohra Ikbal  3 , Majida El Wahidi  4 , Mostafa Kandil  5 , Mohammed El Amraoui  4 , Aziz Fassouane  6
Affiliations

Activity of Haliscosamine against Fusarium oxysporum f.sp. melonis: in vitro and in vivo analysis

Belakssem El Amraoui et al. Springerplus. .

Abstract

Marine sponges are a potential source of new molecules with diverse biological activities. We have previously isolated a sphingosine derivative, (9Z)-2-amino-docos-9-ene-1,3,13,14-tetraol (Haliscosamine) from the Moroccan sea sponge Haliclona viscosa. The aim of this study was to test Haliscosamine in vitro and in vivo for its antifungal activity against Fusarium oxysporum f.sp. melonis causing fusarium wilt of melon. Overall, in vitro test showed that haliscosamine has a similar effect as DESOGERME SP VEGETAUX®. In addition, in vivo showed a significant effect against Fusarium oxysporum f.sp. melonis. Taking to gather, our results suggest that haliscosamine constitutes a potential candidate against Fusarium oxysporum f.sp. melonis and the possibility to use in phytopathology.

Keywords: Fusarium oxysporum; Haliclona; Haliscosamine; Marine sponges; Porifera.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Example of in vitro antifungal activity of Haliscosamine (Ha) and DESOGERME SP (PC) against Fusarium oxysporum f.sp. melonis .
Figure 2
Figure 2
Average infected seedlings according to the in vivo treatment (NCI: Negative control infested, NCU: Negative control Uninfested, PC: positive control, Ha: Haliscosamine).
Figure 3
Figure 3
Percentages of seedlings infected with the pathogen in each treatment and in the controls (NCI: Negative control infested, NCU: Negative control Uninfested, PC: positive control, Ha: Haliscosamine).
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. Acosta AL, Rodriguez AD. 11-oxoaerothionin: a cytotoxic antitumor bromotyrosine-derived alkaloid from the Caribbean marine sponge Aplysina lacunosa. J Nat Prod. 1992;55(7):1007–1012. doi: 10.1021/np50085a031. - DOI - PubMed
    1. Akiyama T, Ueoka R, van Soest RW, Matsunaga S. Ceratodictyols, 1-glyceryl ethers from the red alga-sponge association Ceratodictyon spongiosum/Haliclona cymaeformis. J Nat Prod. 2009;72(8):1552–1554. doi: 10.1021/np900355m. - DOI - PubMed
    1. Askarne L, Talibi I, Boubaker H, Boudyach EH, Msanda F, Saadi B, Serghini MA, Ait Ben Aoumar A. In vitro and in vivo antifungal activity of several Moroccan plants against Penicillium italicum, the causal agent of citrus blue mold. Crop Prot. 2012;40:53–58. doi: 10.1016/j.cropro.2012.04.023. - DOI
    1. Bao B, Sun Q, Yao X, Hong J, Lee CO, Sim CJ, Im KS, Jung JH. Cytotoxic bisindole alkaloids from a marine sponge Spongosorites sp. J Nat Prod. 2005;68(5):711–715. doi: 10.1021/np049577a. - DOI - PubMed
    1. Bao B, Sun Q, Yao X, Hong J, Lee CO, Cho HY, Jung JH. Bisindole alkaloids of the topsentin and hamacanthin classes from a marine sponge Spongosorites sp. J Nat Prod. 2007;70(1):2–8. doi: 10.1021/np060206z. - DOI - PubMed

LinkOut - more resources