Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2014 Dec;4(Suppl 3):S147-52.
doi: 10.4103/2231-0762.149022.

Hemophilia A: Dental considerations and management

Shilpa Padar Shastry  1 , Rachna Kaul  1 , Kusai Baroudi  2 , Dilshad Umar  3
Affiliations
Review

Hemophilia A: Dental considerations and management

Shilpa Padar Shastry et al. J Int Soc Prev Community Dent. 2014 Dec.

Abstract

Aim: To review hemophilia A with emphasis on its oral manifestations, investigations, and dental management.

Materials and methods: Search was conducted using internet-based search engines, scholarly bibliographic databases, PubMed, and Medline with key words such as "Hemophilia A," "factor VIII," "bleeding and clotting disorders," and "dental management."

Results: Hemophilia comprises a group of hereditary disorders caused due to the deficiency of one or more clotting factors leading to prolonged clotting time and excessive bleeding tendencies. It is broadly divided into hemophilia A, B, and C, which occur due to deficiency of factor VIII, IX, and XI, respectively. Hemophilia A is an X-linked recessive hereditary disorder and is the most common of the three, accounting for 80-85% of the cases.

Conclusion: Understanding this complex entity is very important for a dentist to provide appropriate dental treatment and avoid undesirable consequences.

Keywords: Bleeding disorder; Royal disease; bleeding time; clotting disorder; clotting time; factor VIII; hemophilia A.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest: None declared.

References

    1. Patton LL. Bleeding and clotting disorders. In: Greenberg MS, Glick M, Decker BC, editors. Burket's Oral Medicine: Diagnosis and Treatment. 10th ed. Hamilton, ON: BC Decker; 2003. pp. 454–77.
    1. Rogaev EI, Grigorenko AP, Faskhutdinova G, Kittler EL, Moliaka YK. Genotype analysis identifies the cause of the “royal disease”. Science. 2009;326:817. - PubMed
    1. Tiuntseva YA, Herreid CF. Hemophilia: The Royal Disease. [Last accessed on 2014 Jul 11]. Available from: http://www.sciencecases.org/hemo/hemo.asp .
    1. Gilchrist GS, Hammond D, Melnyk J. Hemophilia A in a phenotypically normal female with XX-XO mosaicism. N Engl J Med. 1965;273:1402–6. - PubMed
    1. Kumar JN, Kumar RA, Varadarajan R, Sharma N. Specialty dentistry for the hemophiliac: Is there a protocol in place? Indian J Dent Res. 2007;18:48–54. - PubMed