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Comment
. 2015 Jan 26;32(2):135-7.
doi: 10.1016/j.devcel.2015.01.006.

Enhancer trafficking: free throws and three-pointers

Yiliang Wei  1 , David N Arnosti  2
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Enhancer trafficking: free throws and three-pointers

Yiliang Wei et al. Dev Cell. .
Free article

Abstract

Accurate targeting of transcriptional enhancers to the correct promoter poses a significant information problem in higher eukaryotes. Enhancer-core promoter specificity may provide one solution. Reporting recently in Nature, Zabidi et al. (2014) uncover, via a genome-wide analysis approach, two general classes of enhancer-promoter interactions differentially regulating "housekeeping" versus "developmental" genes.

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