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. 2015 Feb 27;589(5):576-80.
doi: 10.1016/j.febslet.2015.01.017. Epub 2015 Jan 24.

VCP/Cdc48 rescues the growth defect of a GPI10 mutant in yeast

Yohei Ohnuma  1 , Takahiro Takata  1 , Junko Kawawaki  2 , Kunihiko Yasuda  3 , Keiji Tanaka  2 , Yoko Kimura  4 , Akira Kakizuka  5
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Free article

VCP/Cdc48 rescues the growth defect of a GPI10 mutant in yeast

Yohei Ohnuma et al. FEBS Lett. .
Free article

Abstract

We identified a yeast mutant with temperature-sensitive growth defects that were rescued by VCP expression. The mutation occurred in GPI10, which encodes a mannosyl transferase for glycosylphosphatidylinositol anchor formation in the endoplasmic reticulum, and caused a Gly469Glu substitution in Gpi10. The mutant exhibited increased unfolded protein response, which was partially rescued by VCP or Cdc48, and showed sensitivity against cell-wall stressors, which were not rescued by VCP. These results suggest a potential link between VCP/Cdc48 and Gpi10 functions in the control of cell growth.

Keywords: Cdc48; Endoplasmic reticulum; GPI-anchor; Gpi10; Temperature-sensitivity; VCP.

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