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Comment
. 2015 Feb;47(2):103-4.
doi: 10.1038/ng.3205.

Big data mining yields novel insights on cancer

Peng Jiang  1 , X Shirley Liu  1
Affiliations
Comment

Big data mining yields novel insights on cancer

Peng Jiang et al. Nat Genet. 2015 Feb.

Abstract

Recent years have seen the rapid growth of large-scale biological data, but the effective mining and modeling of 'big data' for new biological discoveries remains a significant challenge. A new study reanalyzes expression profiles from the Gene Expression Omnibus to make novel discoveries about genes involved in DNA damage repair and genome instability in cancer.

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  • Gene expression analysis identifies global gene dosage sensitivity in cancer.
    Fehrmann RS, Karjalainen JM, Krajewska M, Westra HJ, Maloney D, Simeonov A, Pers TH, Hirschhorn JN, Jansen RC, Schultes EA, van Haagen HH, de Vries EG, te Meerman GJ, Wijmenga C, van Vugt MA, Franke L. Fehrmann RS, et al. Nat Genet. 2015 Feb;47(2):115-25. doi: 10.1038/ng.3173. Epub 2015 Jan 12. Nat Genet. 2015. PMID: 25581432

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