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Comment
. 2015 Apr 15;21(8):1786-8.
doi: 10.1158/1078-0432.CCR-14-2602. Epub 2015 Jan 27.

Intratumor molecular and phenotypic diversity in hepatocellular carcinoma

Jean-Charles Nault  1 , Augusto Villanueva  2
Affiliations
Comment

Intratumor molecular and phenotypic diversity in hepatocellular carcinoma

Jean-Charles Nault et al. Clin Cancer Res. .

Abstract

Hepatocellular carcinoma is a highly heterogeneous disease both at the molecular and clinical levels. Intratumor morphologic and genetic heterogeneity adds a new level of complexity in our understanding of liver carcinogenesis, and it is likely an important determinant of primary and secondary resistance to targeted therapies. Clin Cancer Res; 21(8); 1786-8. ©2015 AACR. See related article by Friemel et al., p. 1951.

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  • Intratumor heterogeneity in hepatocellular carcinoma.
    Friemel J, Rechsteiner M, Frick L, Böhm F, Struckmann K, Egger M, Moch H, Heikenwalder M, Weber A. Friemel J, et al. Clin Cancer Res. 2015 Apr 15;21(8):1951-61. doi: 10.1158/1078-0432.CCR-14-0122. Epub 2014 Sep 23. Clin Cancer Res. 2015. PMID: 25248380

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