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Review
. 2015 Apr;87(4):712-8.
doi: 10.1038/ki.2014.430. Epub 2015 Jan 28.

Dendritic cells and innate immunity in kidney transplantation

Quan Zhuang  1 , Fadi G Lakkis  2
Affiliations
Review

Dendritic cells and innate immunity in kidney transplantation

Quan Zhuang et al. Kidney Int. 2015 Apr.

Abstract

This review summarizes emerging concepts related to the roles of dendritic cells (DCs) and innate immunity in organ transplant rejection. First, it highlights the primary role that recipient, rather than donor, DCs have in rejection and reviews their origin and function in the transplanted kidney. Second, it introduces the novel concept that recognition of allogeneic non-self by host monocytes (referred to here as innate allorecognition) is necessary for initiating rejection by inducing monocyte differentiation into mature, antigen-presenting DCs. Both concepts provide opportunities for preventing rejection by targeting monocytes or DCs.

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Conflict of interest statement

Disclosures:

There are no interests to disclose.

Figures

Figure 1
Figure 1. Innate allorecognition and danger link innate to adaptive immunity after transplantation
Recognition of allogeneic non-self by recipient monocytes is key for generating mature DC that drive graft rejection by T lymphocytes. Danger, which causes inflammation in the graft but is not sufficient for driving rejection, is nevertheless essential for potentiating the adaptive alloimmune response.
See this image and copyright information in PMC

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