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. 1989 Jan 6;243(4887):80-3.
doi: 10.1126/science.2563174.

Chromosome mapping and expression of a putative testis-determining gene in mouse

C M Nagamine  1 , K M Chan, C A Kozak, Y F Lau
Affiliations

Chromosome mapping and expression of a putative testis-determining gene in mouse

C M Nagamine et al. Science. .

Abstract

Isolation and mapping of a mouse complementary DNA sequence (mouse Y-finger) encoding a multiple, potential zinc-binding, finger protein homologous to the candidate human testis-determining factor gene is reported. Four similar sequences were identified in Hind III-digested mouse genomic DNA. Two (7.2 and 2.0 kb) were mapped to the Y chromosome. Only the 2.0-kb fragment, however, was correlated with testis determination. Polymerase chain reaction analysis suggests both Y loci are transcribed in adult testes. A 3.6-kb fragment was mapped to the X chromosome between the T16H and T6R1 translocation breakpoints, and a fourth (6.0 kb) was mapped to chromosome 10. Hence, mYfin sequences have been duplicated several times in the mouse, although they are not duplicated in humans.

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