Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2015 Jun;17(6):749-755.
doi: 10.1016/j.jcyt.2014.12.007. Epub 2015 Jan 24.

Adoptive immunotherapy with the use of regulatory T cells and virus-specific T cells derived from cord blood

Patrick J Hanley  1 , Catherine M Bollard  2 , Claudio G Brunstein  3
Affiliations
Review

Adoptive immunotherapy with the use of regulatory T cells and virus-specific T cells derived from cord blood

Patrick J Hanley et al. Cytotherapy. 2015 Jun.

Abstract

Cord blood transplantation, an alternative to traditional stem cell transplants (bone marrow or peripheral blood stem cell transplantation), is an attractive option for patients lacking suitable stem cell transplant donors. Cord blood units have also proven to be a valuable donor source for the development of cellular therapeutics. Virus-specific T cells and regulatory T cells are two cord blood-derived products that have shown promise in early-phase clinical trials to prevent and/or treat viral infections and graft-versus-host disease, respectively. We describe how current strategies that use cord blood-derived regulatory T cells and virus-specific T cells have been developed to improve outcomes for cord blood transplant recipients.

Keywords: antiviral; cell therapy; cord blood; graft-versus-host disease; immunotherapy; regulatory T cells (Treg); transplant.

PubMed Disclaimer

Figures

Figure 1
Figure 1
the cumulative incidence of garde II-IV acute GVHD by 100 for patients who received ex vivo expanded Tregs (---)and historical controls (⚊). (Adapted from Brunstein et al, 2011;117(3):1061–70).
See this image and copyright information in PMC

References

    1. Sanchez-Fueyo A, Domenig CM, Mariat C, Alexopoulos S, Zheng XX, Strom TB. Influence of direct and indirect allorecognition pathways on CD4+CD25+ regulatory T-cell function in transplantation. Transpl Int. 2007;20(6):534–41. Epub 2007/03/17. - PMC - PubMed
    1. Sakaguchi S. Regulatory T cells: history and perspective. Methods Mol Biol. 2011;707:3–17. Epub 2011/02/03. - PubMed
    1. Barzaghi F, Passerini L, Bacchetta R. Immune dysregulation, polyendocrinopathy, enteropathy, x-linked syndrome: a paradigm of immunodeficiency with autoimmunity. Frontiers in immunology. 2012;3:211. Epub 2012/10/13. - PMC - PubMed
    1. Shen LS, Wang J, Shen DF, Yuan XL, Dong P, Li MX, et al. CD4(+)CD25(+)CD127(low/−) regulatory T cells express Foxp3 and suppress effector T cell proliferation and contribute to gastric cancers progression. Clin Immunol. 2009;131(1):109–18. Epub 2009/01/21. - PubMed
    1. Yu N, Li X, Song W, Li D, Yu D, Zeng X, et al. CD4(+)CD25 (+)CD127 (low/−) T cells: a more specific Treg population in human peripheral blood. Inflammation. 2012;35(6):1773–80. Epub 2012/07/04. - PubMed

Publication types

LinkOut - more resources