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Case Reports
. 1989 Jan;81(2):188-90.
doi: 10.1007/BF00293901.

Presymptomatic testing for Huntington's disease. A case complicated by recombination within the D4S10 locus

A Curtis  1 , F Millan, S Holloway, M Mennie, A Crosbie, J A Raeburn, D J Brock
Affiliations
Case Reports

Presymptomatic testing for Huntington's disease. A case complicated by recombination within the D4S10 locus

A Curtis et al. Hum Genet. 1989 Jan.

Abstract

Presymptomatic testing for Huntington's disease (HD) is possible through the use of restriction fragment length polymorphisms (RFLPs) at the closely linked D4S10 locus. Recombination between the HD and D4S10 loci will occur in 4%-5% of meioses, and is a well-recognised complication of predictive testing. Recombination between RFLPs within the D4S10 locus is a rare event and can usually be ignored. We report a case where such an intra-locus recombination frustrated attempts to predict the chance of a high-risk individual inheriting the HD gene.

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References

    1. J R Coll Physicians Lond. 1986 Jan;20(1):7-14 - PubMed
    1. Nature. 1985 Nov 7-13;318(6041):75-8 - PubMed
    1. Nature. 1983 Nov 17-23;306(5940):234-8 - PubMed
    1. N Engl J Med. 1988 Mar 3;318(9):535-42 - PubMed
    1. N Engl J Med. 1986 Nov 13;315(20):1267-76 - PubMed

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