doi: 10.1016/0888-7543(89)90322-4.
A genetic linkage map of five marker loci in and around the Duchenne muscular dystrophy locus
Affiliations
- PMID: 2563349
- DOI: 10.1016/0888-7543(89)90322-4
Item in Clipboard
A genetic linkage map of five marker loci in and around the Duchenne muscular dystrophy locus
Genomics.
1989 Jan.
Abstract
Linkage analysis of five marker loci in and around the Duchenne muscular dystrophy (DMD) locus, DXS84, DXS206, DXS164, DXS270, and DXS28, was conducted with 499 families. Overall, the best multipoint distances were found to be DXS84-3.7 +/- 0.6 cM-DXS206-1.0 +/- 0.4 cM-DXS164-1.9 +/- 0.6 cM-DXS270-12.0 +/- 1.1 cM-DXS28. A comparison of this linkage map with the established physical map suggests the presence of hot spots for recombination in the DMD locus.
Similar articles
-
Hot spot of recombination within DXS164 in the Duchenne muscular dystrophy gene.Am J Hum Genet. 1989 Sep;45(3):368-72. Am J Hum Genet. 1989. PMID: 2570527 Free PMC article.
-
Assignment of the locus order DXS28-DXS67-DMD as a spin-off from diagnostic DNA marker analysis in a family with Duchenne muscular dystrophy.Clin Genet. 1987 Mar;31(3):192-7. doi: 10.1111/j.1399-0004.1987.tb02794.x. Clin Genet. 1987. PMID: 2882882
-
Localization and cloning of Xp21 deletion breakpoints involved in muscular dystrophy.Hum Genet. 1987 Mar;75(3):221-7. doi: 10.1007/BF00281063. Hum Genet. 1987. PMID: 2881877
-
Molecular analysis of human muscular dystrophies.Muscle Nerve. 1987 Mar-Apr;10(3):191-9. doi: 10.1002/mus.880100302. Muscle Nerve. 1987. PMID: 2882417 Review.
-
Molecular analysis of muscular dystrophy.J Muscle Res Cell Motil. 1988 Feb;9(1):1-8. doi: 10.1007/BF01682143. J Muscle Res Cell Motil. 1988. PMID: 3292577 Review.
Cited by
-
Decade-long application of preimplantation genetic testing for DMD/BMD: analysis of five clinical strategies and embryo recombination patterns.Hum Genet. 2025 Apr;144(4):405-416. doi: 10.1007/s00439-025-02728-y. Epub 2025 Feb 19. Hum Genet. 2025. PMID: 39969580
-
Nonradioactive assay for new microsatellite polymorphisms at the 5' end of the dystrophin gene, and estimation of intragenic recombination.Am J Hum Genet. 1991 Aug;49(2):311-9. Am J Hum Genet. 1991. PMID: 1867193 Free PMC article.
-
An informative polymorphism detectable by polymerase chain reaction at the 3' end of the dystrophin gene.Hum Genet. 1990 Feb;84(3):283-5. doi: 10.1007/BF00200576. Hum Genet. 1990. PMID: 1968037
-
Rapid detection of deletions in the Duchenne muscular dystrophy gene by PCR amplification of deletion-prone exon sequences.Hum Genet. 1990 Feb;84(3):228-32. doi: 10.1007/BF00200564. Hum Genet. 1990. PMID: 2303244
-
Mapping dystrophin gene recombinants in Greek DMD/BMD families: low recombination frequencies in the STR region.Hum Genet. 1995 Oct;96(4):423-6. doi: 10.1007/BF00191800. Hum Genet. 1995. PMID: 7557964
Publication types
MeSH terms
Substances
LinkOut - more resources
Medical
Molecular Biology Databases