Regenerative medicine: targeted genome editing in vivo
- PMID: 25633595
- PMCID: PMC4349243
- DOI: 10.1038/cr.2015.11
Regenerative medicine: targeted genome editing in vivo
Abstract
The CRISPR/Cas system has proven to be a powerful gene editing tool both in vitro and in vivo. A recent flurry of studies of in vivo gene editing using the CRISPR/Cas system bring bright prospects in creating animal models and targeted gene therapy of human genetic diseases.
Comment on
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Correction of a genetic disease by CRISPR-Cas9-mediated gene editing in mouse spermatogonial stem cells.Cell Res. 2015 Jan;25(1):67-79. doi: 10.1038/cr.2014.160. Epub 2014 Dec 5. Cell Res. 2015. PMID: 25475058 Free PMC article.
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