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. 2015 Feb 6;17(3):760-3.
doi: 10.1021/acs.orglett.5b00097. Epub 2015 Jan 29.

Difluorohomologation of ketones

Mikhail D Kosobokov  1 , Vitalij V Levin, Marina I Struchkova, Alexander D Dilman
Affiliations

Difluorohomologation of ketones

Mikhail D Kosobokov et al. Org Lett. .

Abstract

A method for the homologation of ketones with the CF2 fragment is described. The reaction involves silylation, room-temperature difluorocyclopropanation of silyl enol ethers, and selective ring opening of cyclopropanes under acidic conditions. The whole three-step sequence is conveniently performed in a one-pot mode.

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