The off-target effects of nonspecific NK cells
- PMID: 25634612
- DOI: 10.1182/blood-2014-12-616359
The off-target effects of nonspecific NK cells
Abstract
In this issue of Blood, Shah et al describe the onset of severe acute graft-versus-host disease (GVHD) in 5 of 9 patients who received infusions of ex vivo expanded donor natural killer (NK) cells after HLA-matched hematopoietic stem cell transplantation (HSCT).
Comment on
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Acute GVHD in patients receiving IL-15/4-1BBL activated NK cells following T-cell-depleted stem cell transplantation.Blood. 2015 Jan 29;125(5):784-92. doi: 10.1182/blood-2014-07-592881. Epub 2014 Dec 1. Blood. 2015. PMID: 25452614 Free PMC article. Clinical Trial.
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