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Comparative Study
. 1989 Feb 18;1(8634):352-5.
doi: 10.1016/s0140-6736(89)91725-x.

Predisposing locus for Alzheimer's disease on chromosome 21

A M Goate  1 , A R Haynes, M J Owen, M Farrall, L A James, L Y Lai, M J Mullan, P Roques, M N Rossor, R Williamson, et al.
Affiliations
Comparative Study

Predisposing locus for Alzheimer's disease on chromosome 21

A M Goate et al. Lancet. .

Abstract

Linkage between Alzheimer's disease and markers on the long arm of chromosome 21 was investigated in six families affected by disease of early onset. Linkage was confirmed and the disease locus shown to be centromeric to the locus D21S1/S11 on the long arm of the chromosome. It is argued that the data are consistent with the notion that all patients with Alzheimer's disease of genetic aetiology have a predisposing locus on chromosome 21.

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