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Review
. 2015 Jan 15;22(1):183-202.
doi: 10.1016/j.phymed.2014.11.002. Epub 2014 Nov 20.

Naturally occurring plant isoquinoline N-oxide alkaloids: their pharmacological and SAR activities

Valery M Dembitsky  1 , Tatyana A Gloriozova  2 , Vladimir V Poroikov  2
Affiliations
Review

Naturally occurring plant isoquinoline N-oxide alkaloids: their pharmacological and SAR activities

Valery M Dembitsky et al. Phytomedicine. .

Abstract

The present review describes research on novel natural isoquinoline alkaloids and their N-oxides isolated from different plant species. More than 200 biological active compounds have shown confirmed antimicrobial, antibacterial, antitumor, and other activities. The structures, origins, and reported biological activities of a selection of isoquinoline N-oxides alkaloids are reviewed. With the computer program PASS some additional SAR (structure-activity relationship) activities are also predicted, which point toward new possible applications of these compounds. This review emphasizes the role of isoquinoline N-oxides alkaloids as an important source of leads for drug discovery.

Keywords: Activities; Alkaloids; Antibacterial; Anticancer; Isoquinoline; SAR.

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