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. 1989 Jan 1;257(1):291-2.
doi: 10.1042/bj2570291.

Involvement of D-amino acid oxidase in elimination of free D-amino acids in mice

Y Nagata  1 , R Konno, Y Yasumura, T Akino
Affiliations

Involvement of D-amino acid oxidase in elimination of free D-amino acids in mice

Y Nagata et al. Biochem J. .

Abstract

The physiological role of D-amino acid oxidase was investigated by using mutant ddY/DAO- mice lacking the enzyme. Free D-amino acid concentrations in the mutant mice were significantly higher than those of control ddY/DAO+ mice in kidney, liver, lung, heart, brain, erythrocytes, serum and urine. The results suggest that the enzyme is involved in the catabolism of free D-amino acids in the body, and that free D-amino acids are also excreted into urine.

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