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. 1989 Jan 13;179(1):23-31.
doi: 10.1016/0009-8981(89)90019-3.

Clinical significance of a new isoform of serum alanine aminopeptidase; relationship with liver disease and alcohol consumption

G J Sanderink  1 , Y Artur, F Paille, G Siest
Affiliations

Clinical significance of a new isoform of serum alanine aminopeptidase; relationship with liver disease and alcohol consumption

G J Sanderink et al. Clin Chim Acta. .

Abstract

The potential clinical interest of a new isoform of alanine aminopeptidase (AAP) was examined using polyacrylamide gradient gel electrophoresis. This form, called F-AAP, is more proteolyzed than normal serum AAP. It appears to be associated with many liver diseases and is related to cytolysis, but also to elevated GGT levels. The F-AAP form was present in 52% of subjects treated with anticonvulsant drugs and in 64% of subjects consuming more than 44 g of alcohol per day. Analysis of F-AAP may be of interest in detecting effects of drugs and alcohol on the liver.

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