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. 2015 Apr;21(4):589-603.
doi: 10.1016/j.bbmt.2014.12.031. Epub 2015 Jan 29.

NIH Consensus development project on criteria for clinical trials in chronic graft-versus-host disease: II. The 2014 Pathology Working Group Report

Howard M Shulman  1 , Diana M Cardona  2 , Joel K Greenson  3 , Sangeeta Hingorani  4 , Thomas Horn  5 , Elisabeth Huber  6 , Andreas Kreft  7 , Thomas Longerich  8 , Thomas Morton  9 , David Myerson  10 , Victor G Prieto  11 , Avi Rosenberg  12 , Nathaniel Treister  13 , Kay Washington  14 , Mirjana Ziemer  15 , Steven Z Pavletic  16 , Stephanie J Lee  1 , Mary E D Flowers  1 , Kirk R Schultz  17 , Madan Jagasia  18 , Paul J Martin  1 , Georgia B Vogelsang  19 , David E Kleiner  20
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NIH Consensus development project on criteria for clinical trials in chronic graft-versus-host disease: II. The 2014 Pathology Working Group Report

Howard M Shulman et al. Biol Blood Marrow Transplant. 2015 Apr.

Abstract

The 2005 National Institute of Health (NIH) Consensus Conference outlined histopathological diagnostic criteria for the major organ systems affected by both acute and chronic graft-versus-host disease (GVHD). The 2014 Consensus Conference led to this updated document with new information from histopathological studies of GVHD in the gut, liver, skin, and oral mucosa and an expanded discussion of GVHD in the lungs and kidneys. The recommendations for final histological diagnostic categories have been simplified from 4 categories to 3: no GVHD, possible GVHD, and likely GVHD, based on better reproducibility achieved by combining the previous categories of "consistent with GVHD" and "definite GVHD" into the single category of "likely GVHD." Issues remain in the histopathological characterization of GVHD, particularly with respect to the threshold of histological changes required for diagnostic certainty. Guidance is provided for the incorporation of biopsy information into prospective clinical studies of GVHD, particularly with respect to biomarker validation.

Keywords: Allogeneic hematopoietic cell transplantation; Chronic graft-versus-host disease; Consensus; Diagnosis; Histology; Pathology.

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