doi: 10.11919/j.issn.1002-0829.214177.
Combining antidepressants
Affiliations
- PMID: 25642112
- PMCID: PMC4311111
- DOI: 10.11919/j.issn.1002-0829.214177
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Combining antidepressants
Shanghai Arch Psychiatry.
2014 Dec.
Abstract
Treatment-resistant depression is a common problem encountered by psychiatrists. These patients are often difficult to treat effectively. Strategies for addressing patients with treatment-resistant depression include changing medications, adding another antidepressant (antidepressant polypharmacy), and augmenting treatment with a non-antidepressant.
难治性抑郁症是精神科医生面临的一个普遍问 题。这些患者往往难以有效治疗。治疗难治性抑郁症 患者的策略包括换药、增加另一种抗抑郁药（抗抑郁 药联合治疗）以及抗抑郁药以外的增效治疗。
Keywords: Treatment-resistant depression; antidepressant polypharmacy; augmentation; switching antidepressants.
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References
-
- Rush AJ, Trivedi MH, Wisniewski SR, Nierenberg AA, Stewart JW, Warden D, et al. Acute and longer term outcomes in depressed outpatients requiring one or several treatment steps: a STAR*D report. Am J Psychiatry. 2006;163:1905–1917. - PubMed
-
- Thase ME, Rush AJ. When at first you don’t succeed: sequential strategies for anti-depressant nonresponders. J Clin Psychiatry. 1997;58(Suppl13):23–29. - PubMed
-
- Dunner DL, Rush AJ, Russell JM, Burke M, Woodard S, Wingard P, et al. Prospective,long-term,multi-centerstudyof the naturalistic outcomes of patients with treatment-resistant depression. J Clin Psychiatry. 2006;67:688–695. - PubMed
-
- Ostroff RB, Nelson JC. Risperidone augmentation of selective serotonin reuptake inhibitors in major depression. J Clin Psychiatry. 1999;60:256–259. - PubMed
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