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Review
. 2015 Jan 14:8:448.
doi: 10.3389/fnbeh.2014.00448. eCollection 2014.

Spatial memory deficit across aging: current insights of the role of 5-HT7 receptors

Gregory Beaudet  1 , Valentine Bouet  1 , Christelle Jozet-Alves  1 , Pascale Schumann-Bard  1 , François Dauphin  1 , Eleni Paizanis  1 , Michel Boulouard  1 , Thomas Freret  1
Affiliations
Review

Spatial memory deficit across aging: current insights of the role of 5-HT7 receptors

Gregory Beaudet et al. Front Behav Neurosci. .

Abstract

Elderly persons often face biological, psychological or social changes over time that may cause discomfort or morbidity. While some cognitive domains remain stable over time, others undergo a decline. Spatial navigation is a complex cognitive function essential for independence, safety and quality of life. While egocentric (body-centered) navigation is quite preserved during aging, allocentric (externally-centered) navigation-based on a cognitive map using distant landmarks-declines with age. Recent preclinical studies showed that serotonergic 5-HT7 receptors are localized in brain regions associated with allocentric spatial navigation processing. Behavioral assessments with pharmacological or genetic tools have confirmed the role of 5-HT7 receptors in allocentric navigation. Moreover, few data suggested a selective age-related decrease in the expression of 5-HT7 receptors in pivotal brain structures implicated in allocentric navigation such as the hippocampal CA3 region. We aim to provide a short overview of the potential role of 5-HT7 receptors in spatial navigation, and to argue for their interests as therapeutic targets against age-related cognitive decline.

Keywords: 5-HT7R; Alzheimer’s disease; aging; serotonin; spatial cognition.

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